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Native type II collagen in musculoskeletal disorders: current practice and future directions

Year: 2025

Type: article

Abstract: Collagen is a primary structural protein of connective tissue, accounting for over a quarter of all body proteins. Among 29 known collagen types, type II collagen is particularly significant as it forms the foundation of articular cartilage. Unlike hydrolyzed forms, native type II collagen (UC–II) maintains its original chemical structure, enabling it to function as an oral tolerance inducer. Clinical studies demonstrate effectiveness of UC–II in reducing inflammation, alleviating pain, and improving joint function in osteoarthritis and rheumatoid arthritis. A promising development direction involves marinederived collagen preparations with enhanced safety profiles. Large-scale studies are needed to optimize dosage regimens and administration methods.

Source: Medical alphabet

DOI: 10.33667/20785631202517913

Authors: E. A. Nikitina, S. V. Orlova, T. T. Batysheva, N. V. Balashova, M. V. Alekseeva

Institutions: Peoples' Friendship University of Russia, Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4413850527

FWCI:

Cites: 30

Cited by:

Related to: 10