Work

Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity

Year: 2025

Type: article

Abstract: -treated old mice. Collectively, these findings suggest that glycocalyx integrity is a critical determinant of physical function and that glycocalyx-targeted interventions may be a viable therapeutic strategy to treat age-related physical dysfunction.

Source: Aging

DOI: 10.18632/aging.206313

Authors: Daniel R. Machin, Md. Torikul Islam, Alec Malouf, Daniel Nguyen, Mostafa Sabouri, Maryana Boulos, Andrew G. Horn, Kiana M. Schulze, Gwenael Layec, Lisa A. Lesniewski, Anthony J. Donato

Institutions: University of New Mexico, University of Utah, University of New Mexico Health Sciences Center, University of Nebraska at Omaha, VA Salt Lake City Healthcare System

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Institute on Aging, NIH Clinical Center, National Center for Complementary and Integrative Health

Awards: G1817098098, G2067428092, Platelet Immune Responses in Aging and Influenza, G3338008254, G5166879251, G5447085330, G7682734999, G9000117816, G9000150401, G9000153163, G9000178387, G9000192593, G9000224973, G9000243612, G9000244719, Integrative Mechanisms of Vascular Aging

OpenAlex ID: W4413852222

FWCI: 0.253

Cites: 63

Cited by: 1

Related to: 10