m6A and cardiac posttranscriptional regulation: a novel player in heart development and disease
Year: 2025
Type: review
Abstract: The growing body of research on cardiac epitranscriptomic factors has underscored their potential biological roles and impact on heart development and disease. While transcriptional and translational regulation of cardiac genes in the developing heart has been extensively studied, the potential roles of posttranscriptional regulation of cardiac mRNAs remain a significant gap in our understanding. In addition, discrepancies between transcriptomes and proteomes in both embryonic and adult hearts are well recognized, further suggesting an emerging regulatory role of the epitranscriptome in cardiac biology. Here we summarize the current understanding of m6A machinery and associated RNA-binding proteins in the heart and discuss their impact on heart development. By identifying existing knowledge gaps, we aim to provide insights that may inform future research directions.
Authors: Donna Li, Deqiang Li, Jihyun Jang
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,490
Awards: Cardiac regeneration by histone deacetylases, Histone modifier determines chamber-specific cardiomyocyte proportions from human pluripotent stem cell lineage, G4127992923, G6894847270, an unexpected player in the cardiac endothelium regulating myocardial morphogenesis, Endothelial Zinc Transporter Regulates Ventricular Non-Compaction Cardiomyopathy, Novel pathogenesis of LVNC, Role of cardiac m6A methyltransferases
OpenAlex ID: W4413865483