IRANCANSURV : A comprehensive analysis of childhood cancer survival in Iran
Year: 2025
Type: article
Study design: Observational Study
Abstract: We aimed to assess the 5-year survival probability of childhood cancer in Iran, utilizing data from eight population-based cancer registries across the country. The study employed data from 1809 childhood cancer patients aged 0-14 years, diagnosed between 2014 and 2016. Patients underwent active and passive follow-up procedures, and cases with uncertain vital status were excluded. We used the relative survival method to estimate age-standardized net survival probability for childhood cancer in Iran. The 5-year net survival for leukemia was 67.85% (95% confidence interval [CI] = 64.57, 70.90), while for central nervous system (CNS) cancers, it was 48.63% (95% CI = 43.21, 53.82). An analysis of regional disparities revealed a significant discrepancy of 14.56% in the 5-year survival of childhood leukemia, from 56.96 % in West Azerbaijan to 71.52% in Fars province. The geographical disparity in the 5-year survival of childhood CNS cancer became more pronounced, with a staggering 57.33% difference ranging from 73.50% in Khuzestan to 16.17% in Isfahan provinces. The study highlights low childhood cancer survival rates in Iran and calls for a robust surveillance system, public awareness campaigns, implementing national clinical practice guidelines, and financial support from government and NGOs to improve patient outcomes.
Source: International Journal of Cancer
DOI: 10.1002/ijc.70100
Authors: Elnaz Saeedi, Saeed Nemati, Fereshte Lotfi, Allison Domingues, Sepideh Abdi, Habiballah Pirnejad, Maria Cheraghi, Abbas Rezaeianzadeh, Roya Dolatkhah, Nastaran Niami, Azam Bazarafshan, Arash Golpazir, Majid Yaghoobi‐Ashrafi, Saba Alvand, Zahra Ravankhah, Elham Mohebbi, Azin Nahvijou, Kazem Zendehdel
Institutions: University of Oxford, Tehran University of Medical Sciences, Centre international de recherche sur le cancer, University of Bologna, Beth Israel Deaconess Medical Center, Harvard University, Urmia University, Urmia University of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Shiraz University of Medical Sciences, Tabriz University of Medical Sciences, Iran University of Medical Sciences, Kerman University of Medical Sciences, Kermanshah University of Medical Sciences, Mazandaran University of Medical Sciences, Shariati Hospital, Digestive Disease Research Institute, Isfahan University of Medical Sciences, Georgetown University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: World Health Organization
OpenAlex ID: W4413876734