Analysis of Fibroblast Growth Factor from Platelet-rich Fibrin with and without Phototherapy: An Ex Vivo Pilot Study
Year: 2025
Type: article
Abstract: products, PRF does not use any additives like anticoagulants or bovine thrombin, making it more natural and compatible with the body.It forms a special fibrin matrix packed with platelets, white blood cells, and lots of important growth factors such as PDGF, VEGF, IntroductIonAdvancement of regenerative medicine over the past years has been greatly influenced by the development of biocompatible materials and as a novel therapeutic technology aimed at enhancing tissue repair and healing.One such technology is low-level laser therapy (LLLT) or photobiomodulation (PBM)-which has gained prominence due to its noninvasive, safe, and effective approach in promoting biological processes.LLLT utilizes low-intensity light, typically in the red to near-infrared range (390-1100 nm), to stimulate or modulate cellular activity.[1][2][3][4] These light waves are absorbed by photoacceptors within the mitochondria, leading to increased adenosine triphosphate (ATP) production, activation of transcription factors, and upregulation of signaling pathways involved in tissue repair and regeneration.5 Several studies have demonstrated that LLLT can significantly enhance the expression of various growth factors, including keratinocyte growth factor, platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β1), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF).Essential roles of these factors are wound healing, angiogenesis, inflammation modulation, and tissue remodeling.Importantly, LLLT has also been associated with increased mitochondrial activity, which further boosts cell proliferation, differentiation, and protein synthesis, making it an attractive adjunct in regenerative dentistry.Platelet-rich fibrin, or PRF, is a newer kind of platelet concentrate made from a person's own blood that has become popular for helping soft and hard tissues heal better.Unlike older platelet
Source: World Journal of Dentistry
Authors: Varatharajan Kalaivani, Narayanan Vivek, Potluri Leela Ravishankar, Kunka Mohan Ramkumar, Abdul Rahim Nizar Ahmed, Kumar Gayathri
Institution: SRM Institute of Science and Technology
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413878059