Effect of Laser Ablation and Low-level Laser Therapy on Patients with Localized Moderate to Severe Chronic Periodontitis with Type 2 Diabetes Mellitus: A Randomized Split-mouth Clinical Trial
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: to respond with a hyperinflammatory trait.[14][15][16] It is therefore important that periodontal therapy in diabetic patients is able to deal with these multiple levels of host susceptibility, so as to establish periodontal health.Laser de-epithelialization is a rather predictable method, as it creates a unique wound by the instant vaporization of the epithelium, 17,18 Giannelli et al. 19 showed that photoablative removal of the outer gingival epithelium, the pocket epithelial lining, and IntroductIonDiabetes mellitus (DM) and periodontal disease are both chronic diseases that have a multifactorial etiology and have a proven two-way relationship with each other.DM is a proven risk factor for periodontal disease.This increased risk is mediated by the presence of advanced glycation end products (AGEs), 1,2 a decreased capability of neutrophils and monocytes to respond to chemotactic factors, and an impaired microcirculation.These changes result in an increase in the expression of proinflammatory cytokines, as well as alteration of periodontal wound healing.Periodontal disease is associated with a gram-negative, polymicrobial infection of the gingival sulcus, which is difficult to eliminate partly due to the translocation from other intraoral niches.3 However, current evidence indicates the high significance of intraepithelial pathogens, such as Porphyromonas gingivalis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and Treponema denticola within gingival epithelial cells.[4][5][6][7][8][9] The ability of these pathogens within the gingival epithelial cells, to persist after thorough mechanical therapy, provides these key periodontal pathogens the capacity to perpetuate the inflammatory state of the periodontium.[10][11][12][13] This is even more substantial in the diabetic with periodontal disease, where the periodontium is already primed 1-
Source: World Journal of Dentistry
Authors: Ramees Backer, Jasmine Crena, DJ Victor, Prakash PSG, Sangeetha Subramanian
Institution: SRM Dental College
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413878166