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Pyoderma gangrenosum with myeloperoxidase-positive histiocytoid cells

Year: 2025

Type: article

Abstract: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis, typically presenting as painful ulcers. This article reports a unique case of genital PG in a 72-year-old female with myelodysplastic syndrome. The histopathological examination revealed an unusual histiocytic infiltration. Immunohistochemistry showed the positivity of myeloperoxidase positivity along with CD68 positivity. Notably, while histiocytoid Sweet’s syndrome is recognized as a distinct pathological entity, no such classification exists for PG with a histiocytoid predominant infiltrate. Currently, the presence of a neutrophilic infiltrate is a primary criterion for diagnosing PG. These findings highlight the need for revised diagnostic criteria to account for the variability in histopathological presentations of PG and to prevent misdiagnosis.

Source: Egyptian Journal of Dermatology and Venerology

DOI: 10.4103/ejdv.ejdv_59_24

Authors: Veena Kharayat, Siddharth Bhatt, Archana Purumandla

Institutions: INHS Asvini, Indian Navy

Language: English

Topic: Autoimmune and Inflammatory Disorders

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4413878291

FWCI:

Cites: 12

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Related to: 10