Work

Real incidence and management of patients with suspected iodinated contrast media allergy in our area

Year: 2025

Type: article

Abstract: INTRODUCTION: Adverse reactions to iodinated contrast media (ICM) are very common due to its widespread use. Despite the fact that overall incidence of hypersensitivity reactions (HSRs) to ICM is low, the risk of severe outcomes needs a careful patient evaluation and management. METHODS: We conducted a retrospective epidemiological study that included patients referred to our Allergy Unit for suspected allergy to ICM in whom we carried out a protocolized allergic study based on skin and drug provocation tests (DPT). RESULTS: A total of 108 patients were tested and allergy to ICM was confirmed in 29 (26.9%) and assumed in 9 (8.3%). All these patients tolerated DPT with alternative ICM. The most frequently involved contrasts in confirmed HSR were iodixanol and iohexol, and iopromida was the best tolerated. Out of a total of 125 DPT, we obtained 26 positive results with only two systemic reactions (mild). CONCLUSION: In most of the patients in our sample, allergy to ICM was ruled out, and in allergic patients, tolerance to an alternative ICM was established. Our protocol is safe and allows patients to receive ICM in the future.

Source: Allergologia et Immunopathologia

DOI: 10.15586/aei.v53i5.1352

Authors: M. Jesús Trujillo Trujillo, Victoria Villalobos-Violán, Arturo Toledo Gutiérrez, Mar Gandolfo-Cano, Ester Mohedano Vicente, Eloína González-Mancebo

Institutions: Hospital Universitario de Fuenlabrada, Universidad Rey Juan Carlos

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000