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Haemolytic Uraemic Syndrome in an Adult Following Escherichia coli Sepsis: A Case Report

Year: 2025

Type: article

Abstract: This case report describes a previously healthy 43-year-old woman who developed haemolytic uraemic syndrome (HUS) following Escherichia coli sepsis. She presented with vomiting, diarrhoea, fever, right upper quadrant pain, and altered mental status after returning from travel to Bali and Australia. Initial investigations revealed stage 3 acute kidney injury, deranged liver function, anaemia, thrombocytopenia, and raised inflammatory markers. Blood and urine cultures confirmed E. coli, and she was treated with intravenous antibiotics and supportive care. A peripheral blood film showed features of microangiopathic haemolysis, consistent with HUS, although Shiga toxin testing was not reported in this case. Her condition gradually improved with conservative management. This case highlights the need to consider HUS in adults with E. coli sepsis, even without confirmed Shiga toxin, and the importance of prompt supportive treatment.

Source: Cureus

DOI: 10.7759/cureus.91417

Authors: Ummulkhayr Yussuf, Christopher McManus

Institutions: Southport and Ormskirk Hospital NHS Trust, Southport and Formby District General Hospital

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413884103