Water-Soluble Biocompatible Polymers from Sustainable Amino Acid Moieties for Biomedical Applications
Year: 2025
Type: article
Abstract: Amino acids have emerged as sustainable and versatile building blocks for the creation of functional polymers. Harnessing their intrinsic structural diversity and biological relevance enables the design of unique, well-defined, biocompatible, and highly tailorable macromolecules. Beyond their natural abundance, the exceptional biocompatibility of amino acid-derived polymers positions them as promising candidates for a wide spectrum of biomedical applications. Moreover, the diverse reactive functionalities of amino acids (such as carboxylic acid, amine, thiol, and hydroxyl groups) provide a powerful synthetic toolbox, supporting a broad range of polymerization strategies from step-growth to chain-growth mechanisms. This review highlights the recent developments (2015-present) in the synthesis of amino acid-conjugated polymeric architectures and their biomedical applications. By bridging molecular design, polymer chemistry, and bio-functionality, we highlight the transformative potential of these bioinspired materials and anticipate their pivotal role in shaping the next generation of sustainable and therapeutic polymer platforms.
Authors: Priyadarsi De, Anushree Mondal, Debpriya Mandal, Subhadeep Shit
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4413886067