Work

Disseminated superficial actinic porokeratosis with progression to squamous cell carcinoma: a case report

Year: 2025

Type: article

Abstract: Porokeratoses are dermatoses characterized by defective epidermal maturation, leading to the formation of abnormal cornoid lamellae.Disseminated superficial actinic porokeratosis (DSAP) is the most common variant.Malignant transformation into squamous cell carcinoma (SCC) is rare, particularly in immunosuppressed patients.A 70-year-old male with extensive photodamage, no comorbidities or immunosuppression, presented with annular papules and plaques with hyperkeratotic borders on sun-exposed areas.Biopsy of a typical lesion confirmed DSAP, while biopsy of a verrucous lesion on the right lower limb revealed SCC.Surgical excision of the malignant lesion was performed, and acitretin therapy was initiated with a good response.Clinical surveillance in chronic photo-induced dermatoses is of great importance, allowing early diagnosis of potential malignant transformation.

Source: Portuguese Journal of Dermatology and Venereology

DOI: 10.24875/pjdv.25000032

Authors: Alessandra Encarnação-de Morais, Antônio P. Mendes-Schettini, Mara L. Gomes-de Souza, Marcella Caldeira-Camisasca-Souza, Virgínia Vilasboas-Figueiras

Institution: Fundação de Medicina Tropical

Language: English

Topic: Nonmelanoma Skin Cancer Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413888121