Mesenchymal stem cell membrane functionalized vesicles for Baicalein targeted delivery in Alzheimer’s disease
Year: 2025
Type: article
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment. The lack of effective therapeutic strategies underscores the urgent need for disease-modifying therapies. Baicalein (Bai), a natural compound, exhibits multi-target properties and diverse pharmacological activities, positioning it as a promising candidate. However, its therapeutic potential in AD is limited by low bioavailability and inadequate brain accumulation. To overcome these challenges, we developed mesenchymal stem cell membrane-functionalized vesicles for targeted Bai delivery (MSC-Bai-Lipo). Using Box-Behnken response surface methodology, we optimized preparation parameters to achieve high encapsulation efficiency. In AD model mice, MSC-Bai-Lipo demonstrated targeted delivery to lesions, exhibiting superior therapeutic effects by mitigating AD-associated neuronal damage and neuroinflammatory processes.
Authors: Jing Shi, Xiaolan Yang, Honghui Wu, Wenjing Ye, Zhuoting Li, Tianyuan Zhang, Jianqing Gao
Institutions: Hangzhou Medical College, Zhejiang University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,650
Awards: G2096445200, G872421026, G8955837639
OpenAlex ID: W4413890318