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High Affinity Dimeric Uracil-Based Receptor for the Recognition of Adenine Derivatives through Triplex-like Interactions

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Adenine recognition through triplex-like interactions was explored using clamp-shaped artificial receptor 1, bearing two uracil units and an extended naphthalene scaffold. The requisite binding mode was confirmed for 9-ethyladenine in CDCl 3 via NMR investigations. Phase-transfer experiments demonstrated that 1 selectively binds adenosine from an aqueous mixture of four ribonucleosides.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c01309

Authors: Stefano Volpi, Nicola Rivi, Saša Korom, Martina Neri, Wolfgang Knoll, Roberto Corradini

Institutions: University of Parma, Istituto Nazionale Biostrutture e Biosistemi, Danube Private University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Dipartimenti di Eccellenza, Università degli Studi di Parma