Plasma-Engineered PDRN: Surface Charge Neutralization and Nanosizing Enhance Uptake and Regeneration Potential
Year: 2025
Type: article
Abstract: Background: Polydeoxyribonucleotide (PDRN) is increasingly used in dermatology and cosmetic applications owing to its regenerative and anti-aging properties. However, its topical use is limited by its high molecular weight and anionic charge, which restrict skin penetration. Methods: In this study, we employed a nitrogen-oxygen plasma treatment to PDRN to overcome these limitations and characterized its physicochemical properties and in vitro efficiency. Results: Upon plasma treatment, PDRN’s surface charge was attenuated and its hydrodynamic size decreased, leading to improved uptake and markedly increased cell migration activity. Conclusions: These findings suggest that plasma treatment can transform PDRN into a cosmetically viable active ingredient and may provide a general strategy for adapting other high-molecular-weight bioactives for topical delivery.
Source: Pharmaceutics
Authors: Sun Ju Park, Dong-Hwan Lee, Ki Bok Yoon, AhJin Kim, Chae-Yun Jung, Sung Tae Kim, Sofia Brito, Bum-Ho Bin
Institutions: Ajou University, Inje University, Catholic University of Korea
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
Award: G3638702923
OpenAlex ID: W4413895816