Work

A Case of Neurofibromatosis Type 1 With Early Gastric Cancer and Multiple Small Bowel Gastrointestinal Stromal Tumors

Year: 2025

Type: article

Abstract: Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder that primarily affects the skin and nervous system, leading to characteristic skin changes and the development of benign or malignant tumors with a broad spectrum of severity and complications. Gastrointestinal stromal tumors (GISTs) are the most common non-neurological tumors occurring in patients with NF1. The clinical, genetic, and pathological features of these tumors differ significantly from those of sporadic GISTs. Very rarely, other gastrointestinal malignancies, such as small bowel adenocarcinomas, neuroendocrine tumors, and gastric adenocarcinomas, have occurred in patients with NF1. Here, we report a case of multiple duodenal GISTs and early gastric cancer in a patient with NF1.

Source: The Korean Journal of Helicobacter and Upper Gastrointestinal Research

DOI: 10.7704/kjhugr.2025.0034

Authors: Dyne Ahn, Yu Kyung Cho, In Hyoung Choi, Sol Kim, Ilsoo Kim, Donghoon Kang, Jae Myung Park

Institution: Catholic University of Korea

Language: English

Topic: Gastrointestinal Tumor Research and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413898799

FWCI:

Cites: 15

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Related to: 10