Gestational diabetes increases preterm membrane rupture risk through elevated hydroxydesmethylpiperine sulfate levels
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: Gestational diabetes mellitus (GDM) is a metabolic disorder that increases the risk of premature rupture of membranes (PROM). The link between GDM-associated metabolic dysregulation and PROM remains unclear. This study investigates the underlying metabolic mechanisms to identify potential therapeutic targets for improving pregnancy outcomes. Methods: The study involved 354 mothers from the GDM Mother and Child Study (GMCS) at Wuxi People's Hospital, Nanjing Medical University. A regression model assessed the GDM-PROM relationship. Third-trimester serum metabolites were analyzed using ultra-high-performance liquid chromatography and high-resolution mass spectrometry. Results: A higher percentage of women with PROM were diagnosed with GDM (15.7% vs. 32.3%, P=0.005). Although no significant differences were found in 1-h and 2-h glucose levels (P=0.216 and 0.129), fasting glucose was elevated in the PROM group (4.50 [0.43] vs. 4.73 [0.71], P=0.017). Both unadjusted and adjusted models confirmed GDM as a risk factor for PROM (OR: 2.548, 95% CI: 1.341-4.759; P=0.004). After adjusting for confounders, GDM remained positively associated with PROM risk (OR: 2.538, 95% CI: 1.223-5.224; P=0.012). Hydroxydesmethylpiperine sulfate levels were significantly elevated in all study groups. Conclusion: GDM elevates PROM risk by disrupting fetal membrane integrity through metabolic alterations. Elevated hydroxydesmethylpiperine sulfate levels in GDM-PROM cases indicate its potential as a PROM risk biomarker, underscoring the importance of early metabolic screening and glycemic control. Further research should explore this metabolite's mechanisms and therapeutic potential.
Source: Frontiers in Endocrinology
Authors: Ying Li, Rong Lin, Tianshu Zhang, Tianyu Shi, Xingwang Ding, Jinqi Ma
Institutions: Wuxi People's Hospital, Nanjing Medical University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4413901000