Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective To assess the efficacy of mirabegron in patients with intramural ureteral stones (6–10 mm). Methods We prospectively randomized 92 patients with intramural ureteral stones into two groups. Patients in the mirabegron group received 50 mg of mirabegron daily, while those in the tamsulosin group received 0.4 mg tamsulosin daily. All patients were required to use the Urinary Sensation Scale (USS) to assess the urinary urgency and the Visual Analog Scale (VAS) to assess pain. Patients were followed until stone expulsion or for up to 4 weeks. Results All of 80 patients were included in this study. 41 patients in mirabegron group and 39 patients in tamsulosin group as control. The average expulsion time was shorter in mirabegron group than in tamsulosin group (8.4 ± 2.9 vs. 11.2 ± 3.1 days, P < 0.0001). The stone expulsion rate (SER) was higher in mirabegron group than in tamsulosin group on 1 and 2 weeks (36.6% vs. 15.4%, P = 0.031 and 75.6% vs. 43.6%, P = 0.004). However, the SER on 4 weeks had no statistical difference between two groups (P > 0.05). Post-treatment VAS and USS scores were lower in mirabegron group than tamsulosin group (P < 0.05). Conclusion Mirabegron not only accelerates the expulsion of intramural ureteral stones but also relieves renal colic and vesical irritability.
Source: Frontiers in Pharmacology
Authors: Mengjun Dai, Yuhang She, Hao Wang
Institutions: Nanjing Jiangning Hospital, Nanjing Medical University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Nanjing Medical University
OpenAlex ID: W4413901029