Year: 2025
Type: article
Abstract: Polycystic ovary syndrome (PCOS), which is characterized by an imbalance in the hormonal balance that may lead to other health problems if not followed up or treated appropriately, there is no evidence to show that PCOS has a direct effect on the adrenal gland and on adrenal hormones such as Epinephrine, Aldosterone and Cortisol in female laboratory rats, and the aim of the study recognizes the effect of PCOS on the adrenal gland physiological terms. 16 female rats were evenly divided into two groups (8 mice in each group). The first group was the control group, which is a nature rat that was not given any drug, while the second group was given orally 0.2 mg per kg of letrozole to induce PCOS. At the end of the experiment, blood samples were used to evaluate hormones such as Epinephrine, Aldosterone, Cortisol, Estrogen and Testosterone. The result of the study revealed a significant increase in the concentration of the hormone Epinephrine, Estrogen and Testosterone, with a significant decrease in the concentration of Aldosterone and Cortisol. The study concluded that adrenal hormones are affected by PCOS, which leads to pathological changes in the adrenal gland, indicating a decrease in the adrenal gland activity.
Authors: Randa Talib, Hazar S. Saleh, Rozzana M.Said
Institutions: Thi Qar University, Universiti Teknologi MARA
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: University of Thi-Qar
OpenAlex ID: W4413901112