Work

Effects of bifid triple viable capsules dissolving at intestines combined with emergency comprehensive nursing on intestinal microorganism and nutritional status of patients with coronary heart disease after percutaneous coronary intervention

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Objective To evaluate the combined effects of bifid triple viable capsules dissolving at intestines and emergency comprehensive nursing on intestinal microbiota, cardiovascular function, and nutritional status in coronary heart disease (CHD) patients post-percutaneous coronary intervention (PCI). Study design A randomized controlled trial. Place and duration of study This study was conducted at Capital Medical University from March 2023 to January 2024. Methodology A total of 110 CHD patients who underwent PCI were randomized into two groups: the control group (CG, n = 55) receiving routine emergency nursing, and the study group (SG, n = 55) receiving emergency comprehensive nursing combined with bifid triple viable capsules (0.63 g, twice daily). Key outcomes, including left ventricular ejection fraction (LVEF), blood pressure, length of hospital stay, psychological well-being, nursing satisfaction, intestinal microbiota composition, and nutritional and lipid profiles, were measured before and after 8 weeks of intervention. Results The SG demonstrated significantly higher improvements in LVEF and blood pressure and shorter hospital stays compared to the CG ( p < 0.05). Psychological well-being, self-efficacy, and nursing satisfaction scores were significantly better in the SG ( p < 0.05). Additionally, the SG showed greater restoration of lactobacillus and bifidobacterium levels and reduction in escherichia coli levels ( p < 0.05). Nutritional markers, including hemoglobin, albumin, transferrin, and prealbumin, as well as lipid profiles, such as TG, TC, LDL-C, and HDL-C, improved significantly in the SG compared to the CG ( p < 0.05). Conclusion The combination of bifid triple viable capsules and emergency comprehensive nursing significantly improved cardiovascular function, reduced complications, enhanced self-efficacy and quality of life, and optimized intestinal microbiota and nutritional status in CHD patients after PCI.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1649671

Authors: Ming Zuo, Zhi Liu

Institutions: Capital Medical University, Xuan Wu Hospital of the Capital Medical University

Language: English

Topic: Probiotics and Fermented Foods

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801