A Multicenter, Retrospective Analysis of Long-Term Survival in 255 Dogs With Pheochromocytoma Treated With Alpha-Adrenoreceptor Antagonists or Surgery (2010–2021)
Year: 2025
Type: article
Abstract: BACKGROUND: The survival of dogs with pheochromocytoma (PCC) treated with adrenoreceptor antagonists has not been described or compared to surgically managed cases. HYPOTHESIS/OBJECTIVES: The objective of this study is to evaluate the survival of medically and surgically managed dogs with PCC and investigate factors associated with survival. ANIMALS: Two hundred fifty-five dogs with PCC, treated with alpha-adrenoreceptor antagonists (AA) without adrenalectomy (Group 1, n = 75), adrenalectomy +/- AA (Group 2, n = 128), or neither treatment (Group 3, n = 52). METHODS: Retrospective, multicenter review of medical records. Median overall survival time (OST) for Groups 1 and 2 combined was calculated using Kaplan-Meier estimates, and then compared between Group 1 and Group 2 using Log-Rank testing. Cox proportional hazard analysis identified factors associated with survival in Groups 1 and 2 individually and combined. RESULTS: Median OST for all cases was 854 (95% CI: 572-1136) days. Median OST was lower in Group 1 (247 days, 95% CI: 76-418 days) than in Group 2 (927 days, 95% CI: 587-1267 days; p < 0.001). In Group 2, 88/92 dogs (97.8%) that received presurgical AA treatment survived to discharge compared to 23/27 (85.2%) that did not receive AA pretreatment (p = 0.03). Lack of clinical signs at presentation was associated with increased survival in both groups combined (HR 0.5; 95% CI 0.3-0.9; p = 0.02) and in Group 2 alone (HR 0.3; 95% CI 0.1-0.7; p = 0.01). CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with PCC treated with adrenalectomy have longer survival compared to those managed with AA without adrenalectomy.
DOI: 10.1111/jvim.70220
Authors: Matthew M. E. Steele, Marit F. van den Berg, Sara Galac, Ana M. Dordio, Anna Threlfall, Cláudia Gomes, Amanda Paul, Mirja Nolff, Nadja Sieber-Ruckstuhl, Ghita Benchekroun, Fergus Allerton, Beatriz Mendoza, Susanna Spence, Paula Valiente, Alisdair Boag, Federico Fracassi, Alejandra Carranza Valencia, Jorge Pena-Ramos, Ben Lloyd-Bradley, Mayank Seth, Jack Fawsitt, Fang Yu Foo, Romy M. Heilmann, Paolo Silverstrini, Aurélie Lyssens, Emilie Vangrinsven, Clara Casas-Acuna, Alenka Hrovat, Carolina Arenas, Mario Cervone, Carmel T. Mooney, Rodolfo O. Leal, Karolina Maria Piekos, Gerard Olivares, Guillame Ruiz, Sarah J. Caulfield, Sophie Keyte, Anaïs Lamoureux, Christopher J. Scudder, Ruth Gostelow
Institutions: Royal Veterinary College, Pipestone (United States), Abbotsford Veterinary Clinic, Utrecht University, Veterinarians Without Borders, University of Cambridge, University of Zurich, École Nationale Vétérinaire d'Alfort, WEK Tierarzt, North Downs Hospital, University of Edinburgh, University of Bologna, University of Bern, University of Bristol, Leipzig University, University of Liverpool, University of Pennsylvania, University of Liège, University College Dublin, University of Lisbon, Altrincham Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,000
OpenAlex ID: W4413902436