Work

CX3CR1 modulates acute disc herniation-induced pain via regulating local inflammation and spinal microglia activation

Year: 2025

Type: article

Source: Osteoarthritis and Cartilage

DOI: 10.1016/j.joca.2025.08.017

Authors: Li Xiao, Yi Zhang, Yuan Xing, Hanzhi Yang, Mia A. Shen, Nina E. James, Sun-Sang J. Sung, Chia-Yi Kuan, Li Jin, Xudong Li

Institutions: University of Virginia, Second Xiangya Hospital of Central South University

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: North American Spine Society, National Institute of Neurological Disorders and Stroke, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: An ex vivo system to model the inflammatory microenvironment of human disc herniation, Disc-on-a-chip: microfluidic nutrition and biomechanical loading integrated mouse disc culture system, Targeting stage specific influxed monocytes to treat acute and chronic back pain, CMRO2 and Uncoupling of Oxidative-Phosphorylation in Experimental HIE, Treating neurotoxicity and cognitive deficits due to hyperphosphorylated tau., Deciphering Macrophage Phenotype and Function in Disc Herniation and associated Back/leg Pain

OpenAlex ID: W4413903574

FWCI: 1.122

Cites: 55

Cited by: 2

Related to: 10