Figure S5 from CRISPR Screens Identify POLB as a Synthetic Lethal Enhancer of PARP Inhibition Exclusively in BRCA-Mutated Tumors
Year: 2025
Type: other
Abstract: Supplementary Figure S5. Body weight of the animals is not impacted by the treatment with niraparib – related to Figure 6. A) Effect on body weights of animals containing MDA-MB-436 sgIntron or sgPOLB xenografts treated with vehicle and niraparib at 15 mpk once daily for 28 days. Data is represented as % change in body weights until day 28. B) Effect on body weights of animals containing DLD-1 BRCA2 null sgIntron or sgPOLB xenografts treated with vehicle and niraparib at 30 mpk (left) and 60 mpk (right) once daily for 20 days. Data is represented as % change in body weights until day 20.
Authors: Katherine Lazarides, Justin L. Engel, Michele Meseonznik, Tianshu Feng, Ashley H. Choi, Yi Yu, Shangtao Liu, Samuel R. Meier, Hongxiang Zhang, Binzhang Shen, Robert Tjin Tham Sjin, Douglas A. Whittington, Brian J. McMillan, Brian Doyon, Xuewen Pan, Erik Wilker, Alan Huang, Jannik N. Andersen, William D. Mallender, Madhavi Bandi
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413905591