Figure S2 from CRISPR Screens Identify POLB as a Synthetic Lethal Enhancer of PARP Inhibition Exclusively in BRCA-Mutated Tumors
Year: 2025
Type: other
Abstract: Supplementary Figure S2. POLB knockout alone does not induce synthetic lethality in cancer cell lines across multiple lineages - related to Figure 2. Viability is not impacted in POLB knockout cells as evidenced by the DepMap Public (Q1 2022) CRISPR screening data sets.
Authors: Katherine Lazarides, Justin L. Engel, Michele Meseonznik, Tianshu Feng, Ashley H. Choi, Yi Yu, Shangtao Liu, Samuel R. Meier, Hongxiang Zhang, Binzhang Shen, Robert Tjin Tham Sjin, Douglas A. Whittington, Brian J. McMillan, Brian Doyon, Xuewen Pan, Erik Wilker, Alan Huang, Jannik N. Andersen, William D. Mallender, Madhavi Bandi
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413905653