Figure 6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models
Year: 2025
Type: other
Abstract: High–fiber-purified diet, but not chow, modestly enhances ICB efficacy in a breast cancer mouse model. A, Mean tumor volumes (calculated as the total volume of all individual mammary tumors per mouse) of MMTV-PyMT mice fed the indicated diets, with or without anti–PD-1 treatment. B, Fraction of mice free of a single primary tumor larger than 2,000 mm3. For A and B, n = 5 for isotype control and n = 10 for anti–PD-1 groups. C and D, Percentage of neutrophils and B cells among CD45+ cells in primary tumors collected at endpoint. n = 6 to 8 tumors collected from five mice for no treatment and 10 to 12 tumors from nine mice for anti–PD-1. *, P < 0.05. The log-rank test for B and an ANOVA with the Tukey post hoc test for other panels. Values are mean ± SEM.
Authors: Asael Roichman, Gabriela Reyes-Castellanos, Ziqing Chen, Zihong Chen, Sarah J. Mitchell, Michael R. MacArthur, Akshada Sawant, Llewelyn Levett, Jesse R. Powers, Victoria Burgo, Maria Gomez-Jenkins, Maria Ibrahim, Xincheng Xu, Beianka Tomlinson, Xiang Hang, Eric G. Pamer, Yong Wei, Yibin Kang, Eileen P. White, Joshua D. Rabinowitz
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413906743