Figure 3 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models
Year: 2025
Type: other
Abstract: Grain-based chow favors ICB efficacy in MC-38 allografts, independently of dietary fiber. A, Study design for transplantable tumor models shown in Fig. 3 and 4. The first two MC-38 experiments (B–E) did not include a purified high-fiber dietary arm. Chow is intrinsically high fiber. B and C, Mean tumor volumes and fraction of mice free of tumors larger than 700 mm3 in mice implanted with subcutaneous MC-38 tumors, fed with chow or a low–fiber-purified diet, and treated with anti–PD-1 or isotype control in a study performed in CRL facilities. n = 8 for isotype control and n = 12 for anti–PD-1 groups. D and E, Same as in B and C but in a study performed in PU facilities. n = 10. F and G, Same as in B and C for mice fed with chow or purified diets with low or high insoluble fiber (cellulose, LC, or HC, respectively) and low or high soluble fiber (inulin). n = 10. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001, two-way ANOVA with the Tukey post hoc test at endpoint (day 38 for F) for B, D, and F andlog-rank test for C, E, and G. Values are mean ± SEM. (A, Created with sciencefigures.org.)
Authors: Asael Roichman, Gabriela Reyes-Castellanos, Ziqing Chen, Zihong Chen, Sarah J. Mitchell, Michael R. MacArthur, Akshada Sawant, Llewelyn Levett, Jesse R. Powers, Victoria Burgo, Maria Gomez-Jenkins, Maria Ibrahim, Xincheng Xu, Beianka Tomlinson, Xiang Hang, Eric G. Pamer, Yong Wei, Yibin Kang, Eileen P. White, Joshua D. Rabinowitz
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413906800