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Supplementary Figure 6 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs

Year: 2025

Type: supplementary-materials

Abstract: Supplementary Figure 6 showing (a to c) binding of the scFv, FDC, IgG and ADC to CD64, CD32 and CD16 Fc-Gamma Receptors by SPR and (d) binding of the same test molecules to human monocytes extracted from PBMCs

DOI: 10.1158/1535-7163.30029702

Authors: Ioanna Stamati, Gokhan Yahioglu, Soraya Diez-Posada, Anja Pomowski, Isabel Perez-Castro, Ashleigh Stewart, Laura Bouché, Antony Constantinou, Benjamin J. Stenton, Savvas Saouros, Bryan Edwards, Sam Ness, Mahendra P. Deonarain

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4413906888

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