Figure 5 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models
Year: 2025
Type: other
Abstract: Dietary cellulose tends to negatively affect ICB efficacy in Pold1D400A/D400A mice. A, Schematic showing Pold1D400A/D400A study design. B, Survival curves of Pold1D400A/D400A mice fed with the indicated HC or LC diets and treated with isotype control or anti–PD-1 antibody. Shown are plots for both sexes combined and males and females separately. n = 11 to 13, n = 6 to 8, and n = 5 to 6 mice per group for both sexes, males, and females, respectively. Overall survival curves are not significantly different. (A, Created with sciencefigures.org.)
Authors: Asael Roichman, Gabriela Reyes-Castellanos, Ziqing Chen, Zihong Chen, Sarah J. Mitchell, Michael R. MacArthur, Akshada Sawant, Llewelyn Levett, Jesse R. Powers, Victoria Burgo, Maria Gomez-Jenkins, Maria Ibrahim, Xincheng Xu, Beianka Tomlinson, Xiang Hang, Eric G. Pamer, Yong Wei, Yibin Kang, Eileen P. White, Joshua D. Rabinowitz
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413906975