Multiomic Analysis Links Neighborhood Disadvantage to Inflammatory Proteins and Tumorigenic Markers in ER+ Breast Cancer Plasma and Tumor Samples
Year: 2025
Type: article
Study design: Observational Study
Abstract: High Resolution Image Download MS PowerPoint Slide Residing in disadvantaged neighborhoods has been linked to worsened survival among Black women with estrogen receptor-positive (ER+) breast cancer (BC), yet the underlying multiomic alterations remain underexplored. To investigate associations between neighborhood deprivation and pretreatment steroid hormones, untargeted metabolites, inflammatory proteins, and tumoral gene expression in women with primary ER+ BC and cancer-free controls, pretreatment plasma was collected from ER+ BC patients ( n = 91) and controls ( n = 141) across three Chicago hospitals. Area deprivation index (ADI) was calculated per participant. Plasma was analyzed via targeted steroid hormone and untargeted metabolomics assays, and Olink’s inflammatory protein panel. Tumor samples ( n = 71) were analyzed using the Nanostring Breast Cancer 360 panel. Single-omic analysis and multiomics integration were performed. Elevated inflammatory proteins were observed in cases and controls from disadvantaged neighborhoods ( p < 0.05), and tumoral gene expression showed upregulation of inflammatory and proliferation-related genes ( p < 0.05). Patients from deprived areas exhibited higher inflammation and antioxidant depletion even within the same tumor grade ( p < 0.05). Neighborhood deprivation correlates with pro-inflammatory, proliferative multiomic profiles that may underlie worsened outcomes.
Source: Journal of Proteome Research
Authors: Hannah Heath, Ashlie Santaliz Casiano, Farizi Fazli, Hannah McGee, Margaret Wright Geise, Ekas Abrol, Oana C. Danciu, Garth H. Rauscher, Ayesha Zaidi, Natalie Pulliam, Elona Liko Hazizi, Sarah Friedewald, Seema Khan, J. Julie Kim, W. Gradishar, Jonna Frasor, Kent F. Hoskins, Zeynep Madak-Erdogan
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Northwestern University, National Institutes of Health, University of Illinois at Urbana-Champaign, National Institute of Food and Agriculture, Feinberg School of Medicine, University of Illinois at Chicago, National Cancer Institute, National Institute of Environmental Health Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, Cancer Center, University of Illinois at Chicago
Awards: G1593674991, G1664539943, G2553958215, G2639496168, G2786289396, 1/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), G3620013422, G4314815125, G4710127240, G5490197611, G6040077253, 3/3: The Chicago Cancer HealthEquity Collaborative (ChicagoCHEC), G8206294605, ChicAgo Center for Health and EnvironmenT (CACHET)
OpenAlex ID: W4413907705