Work

Genetic and Phenotype Mechanisms of Campylobacter in the Induction of Guillain-Barré Syndrome: A Review of Bacterial Virulence

Year: 2024

Type: article

Abstract: Campylobacter, a foodborne pathogen, is one of the most important bacterial agents causing human gastroenteritis. Although Guillain-Barré and other neuropathy syndromes have been observed after infection with microorganisms, most cases of these syndromes have occurred post-infection with Campylobacter bacteria. Campylobacter has several virulence factors, but those factors in the bacterial cell wall have the highest effect on causing neurological syndromes. Campylobacter mimics peripheral nerve gangliosides using virulence factors in its cell wall. For this reason, the immune system attacks bacteria and gangliosides as foreign agents and causes neurological diseases. Genetic and phenotype mechanisms are identified as the culprits behind these disorders, including lipooligosaccharide, capsular polysaccharides, phase variation, and protein glycosylation. Using these mechanisms, Campylobacter transforms into different phenotypes and genotypes, producing various virulence factors leading to neurological diseases.

Source: International Journal of Enteric Pathogens

DOI: 10.34172/ijep.5655

Authors: Rahem Khoshbakht, Saeed Khaledian, Seyyed Hani Mirzadeh

Institutions: Amol University of Special Modern Technologies, Shiraz University

Language: English

Topic: Salmonella and Campylobacter epidemiology

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413908792