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Unlocking New Potential in the Functionalization of Chlorinated Silsesquioxanes: A Rapid and Chemoselective Thiolation Method

Year: 2025

Type: article

Abstract: A highly efficient method was successfully applied for the first time to the functionalization of well-defined chlorinated silsesquioxanes with a range of thiols. Thiolation was rapid (2 to 4 h), quantitative, with complete conversion of the reactants and full chemoselectivity, and proceeded under mild conditions (room temperature). This “click chemistry” approach facilitated the preparation of nine novel compounds, with good to excellent isolated yields (64–92%). The structures and purities of these compounds were comprehensively confirmed using multiple analytical techniques, including 1H, 13C, and 29Si NMR spectroscopy, elemental analysis, and mass spectrometry. Thermogravimetric analysis (TGA) further demonstrated that the synthesized compounds exhibited excellent thermal stability. These characteristics suggest their potential for applications in various domains of science, technology, and medicine.

Source: Molecules

DOI: 10.3390/molecules30173583

Authors: Niyaz Yagafarov, Yujia Liu, Naoto Adachi, Nobuhiro Takeda, Masafumi Unno, Armelle Ouali