Year: 2025
Type: article
Abstract: SUMMARY: Recent advances in single-cell sequencing made it possible to not just analyze a cell's individual expression pattern, but to gain insights into a single cell's genome using the cutting-edge technology single-cell DNA sequencing. Mission Bio is, with the Tapestri platform, one of the few providers of this technology. So far, however, there is only little open-source software available for user-friendly processing and quality analysis of this data type. With scafari, we present a tool that offers easy-to-use data quality control as well as explorative variant analyses and visualization. AVAILABILITY AND IMPLEMENTATION: scafari is implemented as an R Bioconductor package featuring a shiny application and is available at https://bioconductor.org/packages/scafari.
Source: Bioinformatics
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,989
Awards: MyPred - Optimierung der Betreuung junger Individuen mit Prädisposition für myeloische Neoplasien - CP1: Entdeckung neuer genetischer Entitäten, CP2: Darstellung klinischer Phänotypen, CP3: Verbesserung der Behandlungsstrategien, SP3: Behandlung der juvenilen myelomonozytären Leukämie, SP5: Rolle der Monosomie 7, ADDRess - Translationale Forschung für Personen mit DNA Reparaturdefekten - TP1 Koordination, TP6 Klonale Evolution bei der Entwicklung hämatologischer Neoplasien, TP7 Klonale Evolution bei Patienten mit DAADR als Ausdruck der Krankheitsprogression, TP3 Psychosoziale Online-Interventionen
OpenAlex ID: W4413910425