Author response: Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes
Year: 2025
Type: peer-review
Abstract: eLife AssessmentThis study provides important insights into how cryptic pockets play a role in shaping binding preferences of protein-nucleic acid interactions.By combining biochemical assays and state-of-the-art molecular dynamics simulations, mechanism underlying viral protein 35 (VP35) homologs to bind the backbone of double stranded RNA is presented.The evidence is compelling for molecular determinants that suggest two different dsRNA binding modes for VP35 and also underscores the evolutionary importance of these pockets.
Source: eLife
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
Awards: MAXIMIZING STUDENT DIVERSITY IN THE BIOMEDICAL SCIENCES AT WASHINGTON UNIVERSITY, Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments, Decrypting the functional significance of cryptic surfaces by combining simulations and experiments, Understanding and controlling protein energy landscapes by combining simulations and experiments
OpenAlex ID: W4413910831