Genetic Prediction of Erectile Dysfunction Caused by Statins Among Malaysian Cardiac Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Erectile dysfunction (ED) is a significant disorder commonly found in patients with cardiovascular diseases and diabetes mellitus. Recent updates have indicated that statins may also contribute to an increased risk of ED. This cross-sectional genetic study involved 246 cardiac patients attending normal visits at Hospital Universiti Sains Malaysia (USM) Kubang Kerian outpatient clinics. The patients were categorized into four groups: statins with ED (group 1), statins without ED (group 2), diabetes with statin without ED (group 3), and healthy patients without diabetes mellitus and statin use (group 4). Six genes were hypothesized to influence ED: CYP19A1, CYP17A1, SIM1, TP53, NR2F2, and NOS3, with different polymorphisms and variants investigated in this study. Overall, statin therapy was found to have a negative impact on ED by affecting NR2F2-AS1 and NOS3. However, atorvastatin showed varying effects on ED for all genes, with the highest impact observed with CYP17A1 and the lowest with CYP19A1. In conclusion, this study revealed novel findings related to genetic factors influencing ED in Malaysian males during statin use.
DOI: 10.3390/ijms26178447
Authors: Naam Bahjat Ahmed Adeeb, Hadeer Akram Al-Ani, Nur Aizati Athirah Daud, Ruzilawati Abu Bakar, Imran Ahmad, Dzul Azri Mohamed Noor, Zilfalil Bin Alwi
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Funder: Universiti Sains Malaysia
OpenAlex ID: W4413914386