Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide We report a selective dearomative cyclization strategy for the synthesis of 3,4-fused diazabicycles from 3-substituted pyridyl ynamides. The method combines a chemo-, regio-, and stereoselective carbometalation with a regioselective dearomatization, enabling access to a broad range of diazabicyclic scaffolds with varied ring sizes. The protocol accommodates alkyl and aryl Grignard reagents, tolerates diverse functional groups, and supports stereodivergent synthesis, offering a versatile platform for constructing complex fused N -heterocycles with potential relevance to medicinal chemistry.
Source: Organic Letters
Authors: Mohamed Agbaria, Zackaria Nairoukh
Institution: Hebrew University of Jerusalem
Language: English
Topic: Catalytic Alkyne Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funder: Israel Science Foundation
Award: G7177189197
OpenAlex ID: W4413915217