Work

Hemolytic Disease of the Fetus and Newborn due to an Anti-LU1 (anti-Lua) Alloantibody: A Case Report

Year: 2025

Type: article

Abstract: Introduction: Many erythrocyte antibodies have been reported to cause hemolytic disease of the fetus and newborn (HDFN), but Lutheran (LU) alloantibodies are normally not involved in HDFN. Case Presentation: Here we report the obstetrical history of a 29-year-old woman with pregnancy complications due to an anti-LU1 antibody causing fetal anemia and the successful treatment with intrauterine transfusion (IUT). Nonimmune hematological causes for fetal anemia and the presence of further alloantibodies, notably antibodies against low-frequency antigens, could be ruled out. Swiss National Immunohematology Reference Laboratory in Bern carried out a monocyte monolayer assay. The monocyte index was >20%, indicating the presence of a clinical relevant antibody. Conclusion: The diagnosis, acute management, and follow-up of neonates with fetal anemia still represent an important area of activity for maternity/neonatal services. To our knowledge, this is the first reported case of HDFN due to an anti-LU1 antibody requiring IUT.

Source: Transfusion Medicine and Hemotherapy

DOI: 10.1159/000548244

Authors: Elke Weinig, Elke Bäz, Nicole Kaup, Anette Stürzel, Sofia Lejon Crottet

Institutions: University of Freiburg, University Medical Center Freiburg, German Red Cross, Swiss Red Cross

Language: English

Topic: Blood groups and transfusion

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,670