Work

Multi-epitope transplantation enables cross-type neutralization of phylogenetically distant HPV11/6/53 in mice

Year: 2025

Type: article

Abstract: values of 0.528, 0.544, and 0.374 μg, respectively, in mice. This approach demonstrates that multi-epitope transplantation can overcome the phylogenetic barriers between α10 and α6 HPV types, enabling cross-neutralization between high-risk and low-risk types. These findings provide a promising foundation for designing next-generation HPV vaccines with expanded coverage.

Source: iScience

DOI: 10.1016/j.isci.2025.113477

Authors: Ciying Qian, Yujie Xu, Yang Huang, Jie Chen, Yanan Jiang, Jingjia Shen, Fei Gao, Tianyu Ren, Yihan Lu, Shuyue Zhang, Chengzong Zhang, Daning Wang, Lizhi Zhou, Tingting Li, Zhibo Kong, Qingbing Zheng, Hai Yu, Ying Gu, Ningshao Xia, Shaowei Li

Institution: Xiamen University

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, National University's Basic Research Foundation of China, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities, National Key Research and Development Program of China Stem Cell and Translational Research

Awards: G2438847483, G3093113652, G3891731610, G6672664789, G800339584, G8825325225

OpenAlex ID: W4413915852

FWCI:

Cites: 46

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