Ginkgolide B promotes stem cell homing and neuronal differentiation by Wharton's jelly mesenchymal stem cell-derived exosomes in a Parkinson's disease cell model
Year: 2025
Type: article
Abstract: Parkinson Stem cell therapy offers potential benefits for Parkinson ’s disease (PD) through neuronal repair and functional restoration of the brain; however, its effectiveness is hindered by limited cell survival, inadequate differentiation, and low homing of the transplanted cells. Ginkgolide B (GB), a bioactive compound found in Ginkgo biloba , has neuroprotective properties. This study examined the impact of GB on Wharton's jelly mesenchymal stem cells (WJMSCs) and their exosomes for potential use in PD therapy. GB enhanced WJMSC homing by upregulating CXCR4, CXCR7, and SDF-1 while reducing OCT4 and Nanog. GB also increased neural differentiation markers, including CD133, BDNF, and phospho-IGF1-R, accompanied by β-catenin nuclear translocation. Exosomes from GB-treated WJMSCs were larger and more effective in promoting neuronal differentiation, as demonstrated by increased BDNF levels and NeuN-positive cells. These results suggest that GB enhances WJMSC differentiation and exosome function, supporting its use as an adjunct in stem cell–based PD treatments. • Ginkgolide B improves stem cell homing in Parkinson's disease cell model. • Ginkgolide B boosts stem cell traits, promoting shift to neuronal differentiation. • Ginkgolide B activates β-catenin, promoting neuronal differentiation in stem cells. • Ginkgolide B boosts exosome, promoting neuronal differentiation in stem cells. • Ginkgolide B as an adjunct in stem cell therapy for Parkinson's disease.
Source: Journal of Functional Foods
Institutions: Tzu Chi University, Tzu Chi Foundation, Hualien Tzu Chi Medical Center, China Medical University, University of Jordan, Soochow University, Education University of Hong Kong, Saveetha University, Chung Shan Medical University Hospital, Chung Shan Medical University, Taipei Tzu Chi Hospital, Asia University, China Medical University Hospital
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,800
Awards: Development and Application of Salvia Miltiorrhiza Plant Stem Cell as a Nutritional Supplement for Healthy Aging, Skin Rejuvenation and Cardiovascular Disease Prevention, G3977208009, G6164408576, Therapeutic Strategies from Enhanced Human Mesenchymal Stem Cells and Their Potentials as Repair and Regeneration Treatments for Aging and Degenerative Disorders, Exploring the Potential and Molecular Mechanisms of Ohwia Caudata Extract and Its Constituents in Treating Drug-Resistant Non-Small Cell Lung Cancer.
OpenAlex ID: W4413920332