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Atypical Presentation of Anaplastic Lymphoma Kinase–Positive Anaplastic Large T-Cell Lymphoma in a Young Patient With Intramuscular Nodules

Year: 2025

Type: article

Abstract: Anaplastic lymphoma kinase–positive anaplastic large cell lymphoma (ALK+ ALCL) is a rare subtype of T-cell non-Hodgkin lymphoma. It commonly presents at advanced stages with B symptoms and lymphadenopathy. We present an atypical case of an 18-year-old man with progressively worsening bilateral thigh and gluteal pain associated with palpable nodules and intermittent low-grade fevers. An infectious and neoplastic work-up was conducted. After imaging and biopsy, ALK+ ALCL was diagnosed. This case highlights the difficulties and delay in diagnosing and treating ALK+ ALCL in a previously healthy young adult with unusual presentation.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2024.1380

Authors: Megan E. Kelley, Nicholas Joseph DeLuca, Daniel Del Castillo Rix, Jonathan H. Schatz, Rafael E. Hernandez Oquet

Institutions: University of Miami, Jackson Memorial Hospital, Sylvester Comprehensive Cancer Center

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413921774

FWCI:

Cites: 16

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Related to: 10