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Paraneoplastic Hypercalcemia and Other Electrolyte Abnormalities in Localized Ameloblastoma

Year: 2025

Type: article

Abstract: Ameloblastoma is a rare odontogenic tumor that presents as a painless asymptomatic, painless jaw swelling. Hypercalcemia is an uncommon complication that is usually seen in metastatic cases and is caused by parathyroid hormone-related peptide (PTHrP) secretion. We report a case of localized ameloblastoma causing paraneoplastic hypercalcemia mediated by PTHrP, alongside concurrent refeeding syndrome due to malnutrition. Accurate differentiation between electrolyte abnormalities from refeeding syndrome and those caused by PTHrP-induced renal wasting is critical for effective management. Treatment involves a multidisciplinary approach and targeted management of metabolic abnormalities based on their underlying cause.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2025.0224

Authors: Lorvens Decosma, Michael B. Phillips

Institutions: Mayo Clinic, Mayo Clinic in Florida

Language: English

Topic: Oral and Maxillofacial Pathology

Subfield: Oral Surgery

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413921786

FWCI:

Cites: 8

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Related to: 10