Year: 2025
Type: article
Study design: Clinical Trial
Abstract: Stress-induced hyperglycemia is a common and harmful side effect of severe traumatic brain injury (TBI) is stress-induced hyperglycemia which is linked to increased subsequent damage and a poor prognosis. Although intensive insulin therapy (IIT) attempts to address this, its advantages are outweighed by the high risk of hypoglycemia and inconsistent mortality benefit, which makes its ideal use in neurocritical care debatable. The purpose of this study was to compare the safety and effectiveness of an intensive insulin regimen (targeting 80–120 mg/dL) to standard care (<220 mg/dL) in patients with severe traumatic brain injury. Two surgical intensive care units in Libya participated in a prospective, randomized, double-blind. The study included 80 persons with severe TBI (GCS ≤8), 20 of whom received conventional therapy and 60 of whom received IIT. The rate of hypoglycemia (blood glucose <80 mg/dL) was the main outcome. Infection rates, length of stay in the intensive care unit, neurological sequelae, and mortality were secondary outcomes. When compared to standard treatment, intensive insulin therapy dramatically improved neurological outcomes, decreased infection rates, and shortened the length of stay in the intensive care unit. But it was also linked to a noticeably increased risk of hypoglycemia episodes. Importantly, there was no difference in mortality between the two therapy groups that was statistically significant. Although intensive insulin therapy improves neurological recovery and offers substantial clinical advantages for patients with severe TBI, it comes at the expense of a higher risk of hypoglycemia and has no mortality benefit. These results highlight the need for cutting-edge glucose monitoring tools to properly apply strict glycemic control in this susceptible group
Source: Libyan Medical Journal
DOI: 10.69667/lmj.2517319
Author: Ali Amer
Institution: Sirte University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4413924672