Work

Recurrent single-organ cutaneous small-vessel vasculitis with streptococcal infection in a pediatric patient: A case report

Year: 2025

Type: article

Abstract: Single-organ cutaneous small-vessel vasculitis is a specific type of vasculitis. Its recurrence rate is approximately 10%, and it is a serious health issue that can lead to increased healthcare costs. There have been no reports of successful treatment of recurrent necrotizing single-organ cutaneous small-vessel vasculitis in children. We report the case of an 11-year-old Chinese girl who presented with recurrently elevated anti-streptococcal O titers and worsening cutaneous necrosis of the lower extremities. She was diagnosed with streptococcal infection-related recurrent severe single-organ cutaneous small-vessel vasculitis and was successfully treated using a "cocktail" therapy, including antibiotics, plasma exchange, and immunosuppressants. She was followed up for 4 years with no recurrence. In conclusion, recurrent necrotizing single-organ cutaneous small-vessel vasculitis in children can be successfully treated with a "cocktail" therapy containing plasma exchange.

Source: Journal of International Medical Research

DOI: 10.1177/03000605251368334

Authors: Min Yang, Xiuying Chen, Zhihua Zhang, Lijuan Hu, Yannan Guo, Songhui Zhai

Institutions: Sichuan University, West China Second University Hospital of Sichuan University, Maternal and Child Health Hospital of Sichuan Province, West China Medical Center of Sichuan University

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,155