Promoting of Biomechanics’ Properties Incisional Wound Repair by Mesenchymal Stem Cell Transplantation
Year: 2025
Type: article
Abstract: Background: Diabetes mellitus is related to wound healing process impairments and molecular abnormalities of the wound. We aimed to evaluate the therapeutic potential of semi-solid bone marrow as a source of stem cells (SCs) in regenerative medicine. Methods: BMMSCs on day 0. Histologic specimens were stained with hematoxylin and eosin and were stained with trichrome mason. Biomechanic measurements were taken in the wound area. Results: The epidermal thickness was increasing and blood vessels were growing. In the cells group, hair follicle destruction, cellular penetration, diffuse fibrosis, and necrosis were not observed in comparison with the saline and control groups. The Cells group had a higher energy absorption than the Bending stiffness and Maximal Force Ultimate Tensile Strength (UTS) group on day 14 as a result of decreased Bending stiffness and Maximal Force Ultimate Tensile Strength (UTS). Conclusion: According on result of recent study, Stem cells can improve the healing of diabetic incision wounds.
Source: WORLD JOURNAL OF PLASTIC SURGERY
Authors: Maryam Habibi, Jafar Rezaian, Pooria Ali, Rasool Mohammedi, Hassan Ahmadvand, Abolfazl Abaszadeh, Farzaneh Chehelcheraghi
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413929189