Understanding human embryogenesis by building programmable stem cell-based models
Year: 2025
Type: article
Abstract: Stem cell-based embryo models provide an alternative system to study an elusive period of development. Programmed mouse embryo models have recently been generated by activating two endogenous regulatory elements via epigenome editing. In this forum article, we discuss this achievement along with the potential of translating it to engineering models of human embryogenesis.
Source: Trends in Cell Biology
Institution: University of California, Santa Cruz
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $7,030
Funders: California Institute for Regenerative Medicine, University of California, Santa Cruz, California Institute of Regenerative Medicine, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Università Cattolica del Sacro Cuore, National Institutes of Health, National Institute of General Medical Sciences
OpenAlex ID: W4413930206