Work

Emerging role of organoids in cancer research: a transformative tool for personalized medicine and therapeutic testing

Year: 2025

Type: article

Abstract: Organoids, three-dimensional (3D) in vitro models derived from patient tissues or stem cells, have developed into transformative tools in oncology by recapitulating the structural, genetic, and functional heterogeneity of native tumors. move from fundamental research to clinical application. This review outlines key applications of organoids in cancer research, including tumor modeling, high-throughput drug screening, immunotherapy evaluation, and dissection of metastatic mechanisms. Case studies of various cancers highlight their ability to preserve patient-specific genomic alterations and predict treatment outcomes. Although challenges remain in many areas, multidisciplinary advances in bioengineering and multi-omics integration are expected to overcome these limitations, demonstrating the unprecedented potential of this technology.

Source: Clinical and translational reports

DOI: 10.58832/ctr.2025.6.6.1

Authors: Dejun Yang, Xudong Jiang, Changjie Li, Guoqin Fang, Ziran Wei, Wei Wang

Institutions: The People's Hospital of Guangxi Zhuang Autonomous Region, Second Military Medical University, Shanghai Changzheng Hospital, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4413936710