Polystyrene nanoplastics reprogramed pulmonary metabolisms mediated by immune regulation of myeloid hypoxia-inducible factor 1α
Year: 2025
Type: article
Abstract: ) mouse model was employed. A shortened 2-week exposure experiment confirmed the indispensable role of HIF-1α in myeloid cells for metabolic modulation during PS-NP exposure. Spearman correlation analysis identified associations between immune cell populations and HIF-1α-related metabolites, suggesting potential crosstalk between HIF-1α-mediated metabolic alterations and immune changes induced by PS-NPs. Our study reveals the critical role of HIF-1α in myeloid cells in modulating lung metabolism and its potential crosstalk with the immune system, offering novel insights on the progression of NP-induced pulmonary toxicity.
Source: Environment International
Authors: Ziniu Wang, Junran Liu, Wei Guo, Gang Tang, Meilin Lv, Yaquan Liu, Jiexia Cheng, Hua Qin, Yun Ding, Xinyue Yang, Linlin Yao, Liqun Chen, Runzeng Liu, Li Zeng, Chunzhen Shi, Jie Gao, Jianbo Shi, Guangbo Qu, Guibin Jiang
Institutions: Chinese Academy of Sciences, Research Center for Eco-Environmental Sciences, University of Chinese Academy of Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Beijing Technology and Business University, Northeastern University, Shandong University, Tianjin University, Dongguan University of Technology, China University of Geosciences, China University of Geosciences (Beijing), Zhejiang University
Language: English
Subfield: Pollution
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $4,750
OpenAlex ID: W4413950183