Effects of microsurgery on short-term serum neurotransmitter levels and long-term cerebral neurological function in elderly patients with spontaneous intracerebral hemorrhage
Year: 2025
Type: article
Abstract: Objective: This study explores the impact of microsurgery on postoperative serum neurotransmitter levels and long-term neurological outcomes in elderly spontaneous intracerebral hemorrhage (SICH) patients. Methods: A single-center, prospective, and single-arm cohort study was conducted, enrolling 106 elderly SICH patients aged ≥60 years who underwent microsurgical hematoma evacuation within 24 h of onset. Serum levels of glutamate (Glu), gamma-aminobutyric acid (GABA), norepinephrine (NE), and serotonin (5-hydroxytryptamine, 5-HT) were measured before surgery and on postoperative day 7. Neurological outcomes were assessed at 180 days using the modified Rankin Scale (mRS) and Glasgow Outcome Scale (GOS). Subgroup analyses were performed based on hematoma volume (≥30 mL vs. <30 mL), hemorrhage location (basal ganglia, thalamus, or lobar), and preoperative Glasgow Coma Scale (GCS) scores (3-8, 9-12, or 13-15). Pearson correlation analysis evaluated the relationship between neurotransmitter levels and outcomes. Results: < 0.05); opposite trends were seen with GABA and 5-HT. A composite neurotransmitter score showed good prognostic accuracy, with an AUC of 0.894 (95% CI: 0.796-0.992) for mRS > 2 and 0.846 (95% CI: 0.782-0.910) for GOS < 4. Conclusion: Following microsurgical hematoma evacuation in elderly SICH patients, postoperative neurotransmitter profiles were associated with long-term functional outcomes. Persistently high Glu/NE and low GABA/5-HT levels predicted poor recovery, especially in those with large or lobar hematomas.
Source: Frontiers in Neurology
Authors: Yang Zhang, Rujun Pan, Zhengjian Liao, Shaoya Yin
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4413962528