Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy
Year: 2025
Type: article
Abstract: mouse liver cancer model. Similarly, 5-fluorouracil inhibits pseudouridine synthesis and significantly enhances the efficacy of PD-1 inhibition. Overall, our findings demonstrate PUS1 as a critical regulator of tumor immune evasion, and targeting pseudouridine synthesis can enhance immunotherapy efficacy by activating dsRNA-sensing pathways.
Source: Cell Reports
Authors: Fan Wang, Yu Tong, Wenyun Guo, Yifei Qian, Zijun Zhu, Songling Li, Linfeng Li, Qianyu Li, Wei-Qiang Gao, Yanfeng Liu
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
Funders: Innovative Research Team of High-level Local University in Shanghai, National Natural Science Foundation of China, Ministry of Science and Technology of the People's Republic of China, Shanghai Municipal Education Commission, Shanghai Jiao Tong University, Higher Education Discipline Innovation Project, School of Medicine, Shanghai Jiao Tong University, Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
OpenAlex ID: W4413963015