Work

Advancing animal welfare: A natural mating protocol for Xenopus laevis

Year: 2025

Type: article

Abstract: The amphibian Xenopus laevis is an alternative animal model for developmental biology and toxicology. The Frog Embryo Teratogenesis Assay- Xenopus (FETAX) stands as a validated test for ecotoxicology and chemical hazard characterization. Conventionally, fertilized eggs are obtained through adult hormonal injection. In adherence to the 3R principles, our proposed method offers the opportunity to obtain embryos through natural amplexus, rearing adults in controlled conditions that replicate the most favourable environmental parameters.

Source: Laboratory Animals

DOI: 10.1177/00236772251351091

Authors: Elena Menegola, Francesca Di Renzo, Renato Bacchetta, Maria Battistoni

Institution: University of Milan

Language: English

Topic: Animal testing and alternatives

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W4413965065

FWCI: 1.112

Cites: 11

Cited by: 1

Related to: 10