Work

TAVR Patients With Nickel Allergy

Year: 2025

Type: article

Abstract: Transcatheter aortic valve replacement (TAVR) is a preferred treatment option for many patients with severe aortic stenosis, but concerns exist regarding safety in patients with nickel allergy due to metallic valve frames. We report a series of 7 patients with a history of nickel allergy who underwent TAVR. Preprocedural allergy evaluation varied, including patch testing or direct skin contact with valve fragments. None of the patients experienced severe allergic reactions, and all remained free of significant nickel allergy-related symptoms during follow-up. A review of the literature identified only 1 prior case of severe nickel hypersensitivity requiring TAVR valve explantation. Importantly, no consistent correlation was observed between patch test results and clinical outcomes. These findings suggest that TAVR can likely be safely performed in patients with nickel allergy and that routine preprocedural patch testing has questionable utility. Further research is needed to clarify long-term outcomes in this population.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2025.104874

Authors: Stefan Milutinovic, Katarzyna Karpinska-Leydier, Richard A. Chazal

Institution: Florida State University

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $850