Work

Extensive Calcification of the Ventricular Septum in Gene-Positive (MYBPC3) Nonobstructive Hypertrophic Cardiomyopathy

Year: 2025

Type: article

Abstract: IMAGES: We present multimodality imaging of ventricular septal calcification. CASE SUMMARY: A 38-year-old man with asymptomatic gene-positive hypertrophic cardiomyopathy was found to have extensive dystrophic calcification of the ventricular septum. We hypothesized that the extensive ventricular septal calcification would represent an area of severe myocardial fibrosis, resulting in calcification secondary to postsurgical (septal myectomy) changes. TAKE-HOME MESSAGE: Calcification of the ventricular septum is a rare finding, not previously described following septal myectomy, that should prompt a comprehensive evaluation and follow-up with multimodality imaging and testing.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2025.104887

Authors: Prabhjot Hundal, Omar Nahhas, M. Fuad Jan, A. Jamil Tajik, Patrycja Galazka

Institutions: Aurora St. Luke's Medical Center, Aurora Sinai Medical Center

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $850